ISSN 1662-4009 (online)

ey0020.7-6 | Gonadal Function and Fertility Issues in Childhood Cancer Survivors | ESPEYB20

7.6. The impact of vincristine on testicular development and function in childhood cancer

I Clark , MFH Brougham , N Spears , RT Mitchell

Brief summary: This is a systematic review on the effects of vincristine-containing regimens, commonly considered to have low gonadotoxicity, on human prepubertal testis, after the reports of testicular tissue abnormalities and severely impaired fertility due to vincristine exposure in prepubertal rodents.Twenty-four studies were identified that reported testicular development and fertility after treatment with vincristine-containing regimens. Only 9/24 ...